Awareness * Advocacy * Research

Leukotriene Receptor Antagonists

An antileukotriene agent is a drug which functions to oppose the function of leukotrienes, which are fatty compounds produced by the immune system that promote bronchoconstriction, inflammation, microvascular permeability, and mucus secretion in asthma and COPD. They have also been found to provide some control in alone or in combination with H1 and H2 antihistamines.  They are less effective than corticosteroids and are thus less preferred in the treatment of asthma.

Montelukast
Pranlukast
Zafirlukast

Nuggets of Wisdom

Yes, there is such a thing as having an allergic type reaction to temperatures. This is defined as a physical urticaria. Other physical urticarias include Solar, Aquagenic, Pressure, Vibration and Exercise.

Most reactions are pseudo-allergic. By definition, an allergy involves inhaling or consuming an allergen. Physical urticarias have no known allergen. Despite the terminology and medical definitions, systemic reactions can be life threatening.

Cold has an arbitrary definition based on an individual feeling. For a person with a cold urticaria, cold can be defined as any temperature cooler than their own body temperature.

You do not have to be cold to have a reaction to the cold; contact with cold can trigger a reaction.

You can have an allergic type reaction to both cold and heat simultaneously.

Most reactions considered anaphylactic are really anaphylactoid by definition.

Moving to a warmer climate as a treatment for Cold Urticaria is a myth. Warmer climates present their own issues for those with Cold Urticaria.

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