Awareness * Advocacy * Research

Genetics

Genetics control processing of medications / supplements in our body’s cells. When programmed differently than expected, unwanted effects are yielded. Have you heard of a medication that makes everyone else sleepy when they use it, yet you are wired after taking it? You essentially have the opposite reaction. These are not allergies to medications, but most commonly known as adverse side effects. They create an altered drug metabolism.

Cytochrome P450 enzymes are present in most tissues of the body, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including drugs and products of endogenous metabolism such as bilirubin, principally in the liver.

As noted on Wikipedia, There are currently are 57 genes attributed toward the process of clearing chemicals from the body through the use of Cytochrome P450 enzymes’s.

https://en.wikipedia.org/wiki/Cytochrome_P450

For what may be identified as safe to most people, may become toxic to others when the DNA is programmed differently than expected. Tests like these may become beneficial.

http://www.drugstorenews.com/…/rite-aid-offers-new-service-…

Substrates are the medications that you take and are processed by these enzymes. The action that is taken on the substrate is known to either inhibit or increase metabolism.

Individuals with Cold Urticaria are affected by this process.  The identification of P450’s that metabolize Steroids and Antihistamines help physicians know which medications are safe and will improve healthy outcomes or have adverse and in some cases devastating side effects.

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Nuggets of Wisdom

Yes, there is such a thing as having an allergic type reaction to temperatures. This is defined as a physical urticaria. Other physical urticarias include Solar, Aquagenic, Pressure, Vibration and Exercise.

Most reactions are pseudo-allergic. By definition, an allergy involves inhaling or consuming an allergen. Physical urticarias have no known allergen. Despite the terminology and medical definitions, systemic reactions can be life threatening.

Cold has an arbitrary definition based on an individual feeling. For a person with a cold urticaria, cold can be defined as any temperature cooler than their own body temperature.

You do not have to be cold to have a reaction to the cold; contact with cold can trigger a reaction.

You can have an allergic type reaction to both cold and heat simultaneously.

Most reactions considered anaphylactic are really anaphylactoid by definition.

Moving to a warmer climate as a treatment for Cold Urticaria is a myth. Warmer climates present their own issues for those with Cold Urticaria.

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