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Schnitzler syndrome is a rare disorder.  The disorder is diagnosed by a chronic red urticarial rash and elevated levels of monoclonal IgM gammopathy. Symptoms may include flairs of fever, joint inflammation, joint pain, bone pain, and enlarged lymph nodes. A monoclonal gammopathy is the uncontrolled growth of a single clone of plasma cells known as immunoglobulin M or IgM. These proteins are supposed to fight foreign substances in the body such as viruses and bacteria, which is why it is referred to as an autoimmune disorder.

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Nuggets of Wisdom

Yes, there is such a thing as having an allergic type reaction to temperatures. This is defined as a physical urticaria. Other physical urticarias include Solar, Aquagenic, Pressure, Vibration and Exercise.

Most reactions are pseudo-allergic. By definition, an allergy involves inhaling or consuming an allergen. Physical urticarias have no known allergen. Despite the terminology and medical definitions, systemic reactions can be life threatening.

Cold has an arbitrary definition based on an individual feeling. For a person with a cold urticaria, cold can be defined as any temperature cooler than their own body temperature.

You do not have to be cold to have a reaction to the cold; contact with cold can trigger a reaction.

You can have an allergic type reaction to both cold and heat simultaneously.

Most reactions considered anaphylactic are really anaphylactoid by definition.

Moving to a warmer climate as a treatment for Cold Urticaria is a myth. Warmer climates present their own issues for those with Cold Urticaria.

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