Awareness * Advocacy * Research



Cryofibrinogenemia, CryoglobulinemiaCryoglobulins which make up Cryoglobulinemia are abnormal proteins (antibodies) in the blood. These proteins clump together in the cold. This causes the plasma to become thick like maple syrup and deposit clumps in blood vessels.

Cryoglobulinemia is part of a group of diseases that cause damage and inflammation of the blood vessels throughout the body (vasculitis).

More than 90% of cases of cryoglobulinemic vasculitis are associated with hepatitis C infections.

Links to external websites for further research
Vasculitis Foundation
Mayo Clinic
Hopkins Vasculitis

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Nuggets of Wisdom

Yes, there is such a thing as having an allergic type reaction to temperatures. This is defined as a physical urticaria. Other physical urticarias include Solar, Aquagenic, Pressure, Vibration and Exercise.

Most reactions are pseudo-allergic. By definition, an allergy involves inhaling or consuming an allergen. Physical urticarias have no known allergen. Despite the terminology and medical definitions, systemic reactions can be life threatening.

Cold has an arbitrary definition based on an individual feeling. For a person with a cold urticaria, cold can be defined as any temperature cooler than their own body temperature.

You do not have to be cold to have a reaction to the cold; contact with cold can trigger a reaction.

You can have an allergic type reaction to both cold and heat simultaneously.

Most reactions considered anaphylactic are really anaphylactoid by definition.

Moving to a warmer climate as a treatment for Cold Urticaria is a myth. Warmer climates present their own issues for those with Cold Urticaria.

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