Awareness * Advocacy * Research


Allergies and the Skin

Mast Cells

An approach to the patient with Urticaria

Cell Calcium. 2010 Oct;48(4):202-8. doi: 10.1016/j.ceca.2010.09.001. Epub 2010 Oct 12. TRPM8 mediates cold and menthol allergies associated with mast cell activation.                Cho Y1, Jang Y, Yang YD, Lee CH, Lee Y, Oh U.                                                     

Cutaneous Mycology

Treatment of Severe Cold Contact Urticaria with Omalizumab: Case Reports


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Nuggets of Wisdom

Yes, there is such a thing as having an allergic type reaction to temperatures. This is defined as a physical urticaria. Other physical urticarias include Solar, Aquagenic, Pressure, Vibration and Exercise.

Most reactions are pseudo-allergic. By definition, an allergy involves inhaling or consuming an allergen. Physical urticarias have no known allergen. Despite the terminology and medical definitions, systemic reactions can be life threatening.

Cold has an arbitrary definition based on an individual feeling. For a person with a cold urticaria, cold can be defined as any temperature cooler than their own body temperature.

You do not have to be cold to have a reaction to the cold; contact with cold can trigger a reaction.

You can have an allergic type reaction to both cold and heat simultaneously.

Most reactions considered anaphylactic are really anaphylactoid by definition.

Moving to a warmer climate as a treatment for Cold Urticaria is a myth. Warmer climates present their own issues for those with Cold Urticaria.

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